The Antiapoptotic Effects of Melatonin in Neonatal Hypoxic-Ischemic Brain Injury and Adult Ischemic Stroke
نویسنده
چکیده
Cite this article: Wang X (2014) The Antiapoptotic Effects of Melatonin in Neonatal Hypoxic-Ischemic Brain Injury and Adult Ischemic Stroke. JSM Neurosurg Spine 2(4): 1033. *Corresponding author Xin Wang, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA, Tel: 6177324186; Email: [email protected] Submitted: 25 February 2014 Accepted: 07 April 2014 Published: 14 April 2014 Copyright © 2014 Wang
منابع مشابه
Advances in the Cell-based Treatment of Neonatal Hypoxic-ischemic Brain Injury.
Stem cell therapy for adult stroke has reached limited clinical trials. Here, we provide translational research guidance on stem cell therapy for neonatal hypoxic-ischemic brain injury requiring a careful consideration of clinically relevant animal models, feasible stem cell sources, and validated safety and efficacy endpoint assays, as well as a general understanding of modes of action of this...
متن کاملCoarse Tremor as the Only Sign of Perinatal Hemorrhagic Stroke: A Case Report
Background: Tremor which is the most common abnormal movement in the neonatal period might be a benign condition or the result of pathologic events and is divided into two subtypes, namely fine tremor and coarse tremor. Fine tremor is usually benign and results from some metabolic disturbance, such as hypoglycemia. On the other hand, coarse tremor is an indicator of brain insult and should be r...
متن کاملHypoxic-ischemic encephalopathy in a young man due to tramadol overdose
Objective: Tramadol is a synthetic analgesic with two mechanisms. The opioid and non-opioid mechanisms are responsible for tramadol side effects. Non-opioid side effects of tramadol are due to the reuptake inhibitions of serotonin and norepinephrine. Some of the side effects include anaphylactoid reactions, CNS depression, hypoglycemia, hypotension, respiratory depression, seizures, and seroton...
متن کاملOsteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model.
BACKGROUND AND PURPOSE Osteopontin (OPN) is neuroprotective in ischemic brain injuries in adult experimental models; therefore, we hypothesized that OPN would provide neuroprotection and improve long-term neurological function in the immature brain after hypoxic-ischemic (HI) injury. METHODS HI was induced by unilateral ligation of the right carotid artery followed by hypoxia (8% O(2) for 2 h...
متن کاملNeuroprotective and regenerative effects of melatonin on hypoxic-ischemic brain injury in neonatal rats
To investigate the neuroprotective effect of melatonin against hypoxic-ischemic brain injury in neonatal rats and the mechanisms involved. Neonatal rats with hypoxic-ischemic brain injury were treated with melatonin at 0.01 mg per gram body weight for 7 days. The damaged area and volume of the rat brains were quantified by threedimensional (3D) reconstructive technology. Apoptosis, regeneration...
متن کامل